Publications by authors named "R Fujiki"
Children with facial differences, such as repaired cleft lip and palate (CLP), may present with reduced capacity for sensorimotor simulation, particularly in the form of facial mimicry. This study examined whether facial mimicry, emotion recognition, and empathy skills are reduced in children with CLP when compared with sex/age-matched controls. A case-control design was utilized.
View Article and Find Full Text PDFArticle Synopsis
- Misfolding of antibody light chains can cause systemic light chain amyloidosis through aggregation and the formation of problematic structures like the 3D domain swap (3D-DS), which has not been experimentally observed.
- This study utilizes computational methods, including molecular dynamics simulations, to analyze the stability and structural dynamics of the 3D-DS and its failure to maintain its form due to interactions with water molecules.
- The research concludes that the absence of 3D-DS dimers in experiments is likely due to their tendency to collapse rather than form stable tetramers, offering insights for potential developments in antibody design.
Histone modifications are catalyzed and recognized by specific proteins to regulate dynamic DNA metabolism processes. NSD2 is a histone H3 lysine 36 (H3K36)-specific methyltransferase that is associated with both various transcription regulators and DNA repair factors. Specifically, it has been implicated in the repair of DNA double-strand breaks (DSBs); however, the role of NSD2 during DSB repair remains enigmatic.
View Article and Find Full Text PDFFacial Expressions of Emotion in Children with Cleft Lip and Palate.
Cleft Palate Craniofac J
August 2024
Objective: To examine the facial movements children with cleft lip and palate (CLP) employ to express basic emotions. Ability of observers to interpret facial expressions of children with CLP was also considered.
Design: Prospective case-control design.
Socioeconomic Deprivation Detrimentally Influences Language Outcomes in Toddlers With Cleft Palate.
J Speech Lang Hear Res
September 2024
Purpose: The purpose of this study was to examine the influence of socioeconomic deprivation on language and developmental outcomes in toddlers with cleft palate with or without cleft lip (CP ± L). Other factors known to influence language outcomes were also considered, including home language history, history of hearing problems, syndromic diagnoses, and sex.
Method: A multicenter, cross-sectional study design was conducted.