Publications by authors named "R Fucho"
Article Synopsis
- Alcohol-related liver disease (ALD) is a significant cause of chronic liver issues, and the mechanisms behind it are not fully understood, but StARD1 has been identified as an important factor in liver injury.
- Research shows that StARD1 is mainly found in the perivenous (PV) zone of the liver in mouse models of chronic and acute-on-chronic ALD, leading to increased cholesterol and lipid peroxidation in this area.
- The study highlights distinct differences in mitochondrial structure and function between PV and periportal (PP) hepatocytes, showing that alcohol feeding alters these characteristics and underscores the role of StARD1 in liver damage associated with ALD.
Acute fetal cardiovascular adaptation to artificial placenta in sheep model.
Ultrasound Obstet Gynecol
August 2023
Objective: To describe the acute cardiovascular adaptation of the fetus after connection to an artificial placenta (AP) in a sheep model, using ultrasound and invasive and non-invasive hemodynamic assessment.
Methods: This was an experimental study of 12 fetal sheep that were transferred to an AP system, consisting of a pumpless circuit with umbilical cord connection, at 109-117 days' gestation. The study was designed to collect in-utero and postcannulation measurements in all the animals.
Objective: To describe the development of an artificial placenta (AP) system in sheep with learning curve and main bottlenecks to allow survival up to one week.
Methods: A total of 28 fetal sheep were transferred to an AP system at 110-115 days of gestation. The survival goal in the AP system was increased progressively in three consecutive study groups: 1-3 h (n = 8), 4-24 h (n = 10) and 48-168 h (n = 10).
Alcoholic (ASH) and nonalcoholic. (NASH).steatohepatitis are advanced.
View Article and Find Full Text PDFGrowth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features. Recently, it has been reported that GDF11 exerts tumor-suppressive properties in hepatocellular carcinoma cells, decreasing clonogenicity, proliferation, spheroid formation, and cellular function, all associated with a decrement in stemness features, resulting in mesenchymal to epithelial transition and loss of aggressiveness. The aim of the present work was to investigate the mechanism associated with the tumor-suppressive properties displayed by GDF11 in liver cancer cells.
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