Publications by authors named "R Fucci"
Article Synopsis
- * Significant efforts are underway by scientists and engineers to enhance thermoelectric performance by improving our understanding of the underlying physics and optimizing device design.
- * This Roadmap presents recent findings from the Italian research community on enhancing thermoelectric materials and developing more efficient thermoelectric and hybrid devices.
A large proportion of infertile men do not receive a clear diagnosis, being considered as idiopathic or unexplained cases due to infertility diagnosis based on standard semen parameters. Particularly in unexplained cases, the search for new indicators seems mandatory to provide specific information. In the etiopathogenesis of male infertility oxidative stress displays important roles by negatively affecting sperm quality and function.
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- Resveratrol, a sirtuin 1 (SIRT1) activator, shows potential in preventing vascular oxidative stress linked to endothelial dysfunction, but its clinical utility is hampered by low oral bioavailability.
- Researchers used a computational method to identify the best resveratrol derivatives from their chemical library, focusing on those with high SIRT1 activation and bioavailability.
- The most effective derivative was tested in human umbilical vein endothelial cells (HUVECs) damaged by oxidative stress, showing it preserved cell viability and reduced reactive oxygen species, indicating its potential role in activating sirtuins despite being slightly less effective than resveratrol itself.
The homocysteine pathway in the preconception period should be evaluated to highlight micronutrient deficiencies and warrants optimal multivitamin supplementation, before Assisted Reproduction, as preconception care. We conducted a retrospective study aimed at investigating the role of vitamin B complex (5-methyltetrahydrofolate, vitamin B12, vitamin B6) supplement use compared with the role of only folic acid supplement use, in relation to clinical pregnancy and live birth in infertile women undergoing homologous ART. We investigated 269 Caucasian women referred to the Centre for Assisted Reproductive Technology for homologous ART.
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