Publications by authors named "R Frye"
Feeding difficulties are prevalent among individuals with autism spectrum disorder (ASD). Nevertheless, the knowledge about the association between feeding-related early signs and child development remains limited. This review aimed to describe the signs and symptoms related to feeding during child development and to explore their relevance to the diagnosis of ASD.
View Article and Find Full Text PDFBackground & Aims: It has been postulated that carriers of PNPLA3 I148M (CG [Ile/Met] or GG [Met/Met]) develop metabolic dysfunction-associated steatotic liver disease (MASLD) in the absence of insulin resistance or metabolic syndrome. However, the relationship between insulin resistance and MASLD according to the allele has not been carefully assessed.
Methods: A total of 204 participants were recruited and underwent genotyping, an oral glucose tolerance test, liver proton magnetic resonance spectroscopy and percutaneous liver biopsy if diagnosed with MASLD.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children and is associated with physiological abnormalities, most notably mitochondrial dysfunction, at least in a subset of individuals. This systematic review and meta-analysis discovered 204 relevant articles which evaluated biomarkers of mitochondrial dysfunction in ASD individuals. Significant elevations (all p < 0.
View Article and Find Full Text PDFAlcohol consumption may impact and shape brain development through perturbed biological pathways and impaired molecular functions. We investigated the relationship between alcohol consumption rates and neuron-enriched extracellular vesicles' (EVs') microRNA (miRNA) expression to better understand the impact of alcohol use on early life brain biology. Neuron-enriched EVs' miRNA expression was measured from plasma samples collected from young people using a commercially available microarray platform while alcohol consumption was measured using the Alcohol Use Disorders Identification Test.
View Article and Find Full Text PDFArticle Synopsis
- Mitochondria are crucial for tissue health, stress responses, and disease monitoring, leading to a demand for technologies that can analyze their structure and function in various cells.
- The study introduces a new computerized method called MitoTouch that quickly and cost-effectively analyzes mitochondrial shape and network architecture from confocal images, offering over thirty analytical features.
- Using this tool, researchers identified a natural ingredient that helps protect mitochondria from damage caused by oxidative stress, while also demonstrating its effectiveness in distinguishing between different types of human cells, including cancerous ones.