Publications by authors named "R Freynhagen"
Introduction: Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization.
Objectives: This study aimed to investigate the relation between symptoms of central sensitization and sleep disturbances in patients with NP.
Article Synopsis
- * A study of 1,090 patients showed that 30% with neuropathic pain experienced PHS, while only 2% of healthy participants did, and its occurrence was not related to overall pain intensity.
- * PHS may indicate diminished function of small thermosensory fibers that detect temperature; recognizing it can assist in identifying small fiber loss in patients, making it easy for them to self-report.
Neuropathic pain highly affects quality of life, well-being, and function. It has recently been shown based on cluster analysis studies that most patients with neuropathic pain may be categorized into 1 of 3 sensory phenotypes: sensory loss, mechanical hyperalgesia, and thermal hyperalgesia. If these phenotypes reflect underlying pathophysiological mechanisms, they may be more relevant for patient management than underlying neurological diagnosis or pain intensity.
View Article and Find Full Text PDF