Publications by authors named "R Fresch"
Common maternal medical comorbidities such as hypertensive disorders, diabetes, tobacco use, and extremes of maternal age, body mass index, and gestational weight gain are known individually to influence the rate of cesarean delivery. Numerous studies have estimated the risk of individual conditions on cesarean delivery. To examine the risk for primary cesarean delivery in women with multiple maternal medical comorbidities to determine the cumulative risk they pose on mode of delivery.
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- Twin pregnancies with twin-twin transfusion syndrome (TTTS) are at increased risk of preterm birth, and this study aimed to compare cervical length (CL) measurements from transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) as predictors for preterm birth after selective fetoscopic laser photocoagulation (SFLP).
- The research analyzed 626 TTTS pregnancies, revealing that while CL measurements from MRI and TVS were generally correlated (r = 0.63), MRI had limitations in detecting short cervix cases compared to TVS, particularly in those with very short lengths.
- The study concludes that while MRI can provide CL data, TVS may be more reliable for identifying patients at higher risk
Congenital heart disease (CHD) affects nearly 1% of births annually, and CHD pregnancies carry increased risk of developing pathologies of abnormal placentation. We previously reported significant developmental impacts of disrupting Hand1, a gene associated with CHD, expression in placenta trophoblast and endothelial cells in multiple mouse models. In this study, we aimed to build upon this knowledge and characterize the mechanistic impacts of disrupting HAND1 on human placenta trophoblast and vascular endothelial cell gene expression.
View Article and Find Full Text PDFObjective: To describe the pregnancy outcomes of patients who experienced previable and periviable prelabor rupture of membranes (PROM) after the treatment of twin-twin transfusion syndrome.
Methods: We conducted a retrospective cohort study of patients whose pregnancies were complicated by twin-twin transfusion syndrome who were treated with fetoscopic laser photocoagulation at a single fetal center and subsequently experienced PROM from April 2010 to June 2019. Outcomes were infant survival and latency from PROM to delivery.