Publications by authors named "R Fredi Langendonk"

Article Synopsis
  • - The study aimed to determine the prevalence of antibodies to equine epizootic lymphangitis (EL) in horses and donkeys in rural Gambia and identify risk factors for seropositivity.
  • - A total of 555 equids were tested, revealing a seroprevalence of 79.9% in horses and 46.7% in donkeys, with factors like age, sex, and season impacting these rates.
  • - Two models showed that female horses and those from rainy season samples had higher odds of seropositivity, while younger horses and those involved in firewood transportation had lower odds.
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is classified as a priority one pathogen by the World Health Organisation, and new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains. Antimicrobial-resistant nosocomial pathogens such as pose unwavering and increasing threats. Antimicrobial stewardship has been a challenge during the COVID-19 pandemic, with a majority of those hospitalized with SARS-CoV2 infection given antibiotics as a safeguard against secondary bacterial infection.

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Streptococcus pneumoniae is a commensal of the human nasopharynx and a major cause of respiratory and invasive disease. We examined adaptation and evolution of pneumococcus, within nasopharynx and lungs, in an experimental system where the selective pressures associated with transmission were removed. This was achieved by serial passage of pneumococci, separately, in mouse models of nasopharyngeal carriage or pneumonia.

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