Publications by authors named "R Fortrie"
Article Synopsis
- - Mast cell tumors (MCTs) in dogs are categorized into cutaneous (cMCTs) and subcutaneous (scMCTs) types, with differences in tumor origin and the need for proper grading for prognosis.
- - A study analyzed 305 scMCTs and 1291 cMCTs, revealing distinct breed distributions and histopathological features, where scMCTs exhibited more severe characteristics and a higher likelihood of being classified as Kiupel high grade compared to cMCTs.
- - The findings indicate significant histopathological differences between scMCTs and cMCTs, but further research is needed to see how these differences might affect clinical outcomes in dogs.
Canine mast cell tumors (MCTs) are a promising translational model for human mast cell neoplasms with striking similarities such as the Darier's sign and mutations in the KIT gene. Whereas mast cell neoplasms are rare in humans, MCTs are the most frequent malignant neoplasms of the skin in dogs. In human systemic mastocytosis, serum tryptase is an important diagnostic criterion.
View Article and Find Full Text PDFThe racemization mechanism of tert-butylphenylphosphido-borane is investigated experimentally and theoretically. Based on this converging approach, it is shown, first, that several phosphido-borane molecular species coexist at the time of the reaction and, second, that one particular of both initially assumed reactive routes most significantly contribute to the overall racemization process. From our converging modeling and experimental measurement, it comes out that the most probable species to be here encountered is a phosphido-borane-Li (THF) neutral solvate, whose P-stereogenic center monomolecular inversion through a Y-shaped transition structure (Δ G° : 81 kJ mol ) brings the largest contribution to the racemization process.
View Article and Find Full Text PDFIn this article, we explore, both theoretically and experimentally, the general reactivity of alkyl hydrogeno-phenylphosphinates with alcohols. We show that alcohol molecules act exclusively as nucleophilic species, and add to alkyl hydrogeno-phenylphosphinates, leading to pentacoordinated intermediates. These intermediates are shown to subsequently competitively undergo alcohol eliminations and/or Berry pseudorotations.
View Article and Find Full Text PDFObjective: To investigate the repeatability and reproducibility of the presence of a circumferential femoral head osteophyte (CFHO), a curvilinear caudolateral osteophyte (CCO), osteosclerosis of the cranial acetabular edge (Scler CrAE), degenerative joint disease (DJD), and the diagnosis of suspected canine hip dysplasia (CHD) in different groups of experienced observers.
Study Design: Cross-sectional study.
Sample Population: Standard hip extended radiographs (n = 50).