Reproductive effects of the anticancer drug cyclophosphamide in male rats at different ages.

This study was undertaken to determine the effects of the anticancer and immunosuppressant drug cyclophosphamide (CP) on several endpoints of the male rat reproductive system at different ages; 10-day-old (experiment A), 45-day-old (experiment B), and adult (experiment C) Sprague-Dawley rats were injected intraperitoneally with CP at doses of 20 mg/kg/day or/week and 100 mg/kg/week for 2 weeks (experiment A), doses of 20 mg/kg/day for 5 weeks and 100 mg/kg/day for 10 days (experiment B), and doses of 20 mg/kg/day for 5 weeks (experiment C). In all groups CP induced a significant rate of mortality. Body weight gain was moderately to severely reduced in two groups of experiment A (20 mg/kg/day and 100 mg/kg/week) and of experiment B (20 mg and 100 mg/kg/day) but normal in the others.

Influence of germ cells upon Sertoli cells during continuous low-dose rate gamma-irradiation of adult rats.

The effects of continuous gamma-irradiation of adult rats at two low-dose rates (7 cGy and 12 cGy/day; up to a total dose of 9.1 Gy and 10.69 Gy 60Co gamma-ray, respectively) were investigated.

Early effects of gossypol on the testis and epididymis in the rat.

In a previous study we showed that the administration of gossypol to rats for 34 days caused 2 types of modification of the epididymis: (1) the secretion of carnitine and inositol were reduced in the fluid, (2) the spermatozoa lost their motility and showed major morphological changes (head-flagella dissociation). We wished to clarify the early effects of gossypol on the epididymis. Sprague Dawley adult rats (350 g) were forced fed with gossypol at a dose of 25 mg/kg/day for 17 days.