Publications by authors named "R Fock"
Magnesium (Mg) is essential for life, and low levels impair immune function, promote chronic inflammation, and influence the intestinal microbiome, with the peritoneal cavity serving as a site for direct interaction between the cavity and intestinal contents, including the microbiota. This study investigates the effects of a Mg-restricted diet on peritoneal immune cells and its interplay with the intestinal microbiome. Male C57BL/6NTaq mice were divided into three groups: control, restricted, and restored.
View Article and Find Full Text PDFMalaria continues to afflict hundreds of millions of lives annually, causing substantial fatalities despite available vaccines endorsed by the World Health Organization (WHO). However, these vaccines lack efficacy against Plasmodium vivax (Pv). Concomitantly, a considerable part of residents from several Pv-endemic areas face malnutrition, compromising their immunity to diseases, including malaria.
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- - The Brazilian Rare Diseases Network (RARAS) was established in 2020 to conduct a nationwide epidemiological survey on rare diseases (RDs) in Brazil, addressing the lack of comprehensive national data since the Comprehensive Care Policy for RDs began in 2014.
- - A total of 12,530 patients were surveyed, with a median age of 15 years; significant findings included that 63.2% had confirmed diagnoses, primarily of phenylketonuria, cystic fibrosis, and acromegaly, and average diagnostic delays lasting 5.4 years.
- - The majority of diagnoses and treatments were funded by the Public Health System, with notable rates of hospitalization (44.5%) and a mortality rate
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- Hypertriglyceridemia (HTG) is linked to cardiovascular disease and pancreatitis, with severe cases often having genetic causes, and this study focused on Brazilian patients with severe HTG.
- A cohort of 212 patients with extremely high triglyceride levels was analyzed, resulting in 13% having identifiable pathogenic genetic variants, while 80% of detected variants were classified as Variants of Unknown Significance (VUS).
- The study identified common gene mutations associated with severe HTG and reported 16 new genetic variants, contributing valuable information for genetic counseling and healthcare in Brazil.
Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system.
Cytokine Growth Factor Rev
April 2024
The bone marrow is a haven for hematopoietic and non-hematopoietic cells, creating complex micro-anatomical regions called niches. These distinct niches all participate in an intricate orchestra of cellular interactions that regulates the hematopoietic stem cell and its progenies. In this review, we provide a detailed description of the three most well-known bone marrow niches and their participation in hematopoiesis.
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