Publications by authors named "R Florido"
Context: Transitions in metabolic health status over time are strongly linked to risk for cardiovascular events, particularly among individuals with obesity. Adipokines are proteins with metabolic effects, but their role in transitions in metabolic health status over time is unknown.
Objective: To evaluate the associations of adiponectin and leptin with metabolic risk transitions over time.
Article Synopsis
- A study investigated the relationship between waist circumference (WC) and body mass index (BMI) with the incidence of cancer, focusing on cumulative waist circumference (waist circumference-years) over time instead of just single measurements.
- The research utilized serial WC measurements from a 9-year longitudinal study involving over 10,000 participants and analyzed cancer risk using Cox proportional hazards regression.
- Results indicated that waist circumference-years are positively associated with obesity-related cancers, but did not offer significant predictive value beyond traditional WC and BMI measurements, suggesting that BMI might be more practical for routine clinical assessment.
Background And Aims: Several studies reported an increased cancer risk related to lower-extremity peripheral artery disease (PAD) but had important caveats: not accounting for key confounders like smoking, follow-up <10 years, or no race-specific results. To assess the long-term independent association of PAD with cancer incidence in a bi-racial community-based cohort.
Methods: We categorized 13,106 ARIC participants without cancer at baseline (mean age 54.
Background: Cardiovascular disease (CVD) and cancer frequently co-occur due to shared risk factors such as obesity, which is linked to CVD and 14 cancer types. This study explores whether CVD pathophysiologies, combined with obesity, increase cancer risk, impacting clinical management.
Methods And Results: Data from the ARIC (Atherosclerosis Risk in Communities) study, spanning 28 years, were analyzed.
Article Synopsis
- Immune-checkpoint inhibitors (ICIs) can lead to serious heart issues like myocarditis, which can also involve broader muscle-related symptoms, highlighting the need for understanding associated risks.
- A study conducted across 17 countries from 2014 to 2023 examined data from 748 patients to identify factors that predict severe outcomes related to these heart complications, using a statistical model for analysis.
- Key findings indicated that certain conditions (like active thymoma) and symptoms (like low heart function) significantly increased the risk of severe heart-related events, and a risk score created from these factors effectively predicted outcomes, validated in multiple cohorts.