Tirzepatide: Clinical review of the "twincretin" injectable.

Purpose: To provide an overview of the safety and efficacy, pharmacology, dosing, place in therapy, and clinical trials for tirzepatide, a novel glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) agonist for treatment of type 2 diabetes.

Summary: Diabetes is a chronic disease state with a high burden on healthcare spending and patient quality of life. Incretin-influencing agents such as GLP-1 receptor agonists have gained favor as diabetes therapeutic options due to their impact on multiple glycemic factors as well as resulting weight loss and cardiovascular benefits.

Improving Antibiotic Stewardship among Asymptomatic Newborns Using the Early-onset Sepsis Risk Calculator.

Introduction: Neonatologists have long struggled with identifying and treating early-onset sepsis (EOS) without overexposing newborns to unnecessary antibiotics.

Methods: In January 2016, we instituted an EOS protocol based mainly on the 2012 AAP guidelines. We subsequently conducted 2 additional plan-do-study-act cycles to decrease antibiotic usage by integrating the EOS risk calculator into our algorithm.

Negative Consequences of Alcohol Use among People Living with HIV.

Among people living with HIV (PLWH), alcohol use can have negative impacts beyond HIV-related outcomes. The objectives of this study are to identify the most common alcohol-related consequences among PLWH in Florida and describe factors associated with experiencing more alcohol-related consequences. Data were collected from PLWH in the Florida Cohort study who drank at least monthly in the past year (n=397).

Perceived Positive Consequences Are Associated with Unhealthy Alcohol Use Among Persons Living with HIV.

Background: Understanding how perceived positive consequences are associated with drinking may help improve effectiveness of alcohol reduction interventions among people living with HIV (PLWH). We aimed to determine whether perceived positive consequence scores varied by sociodemographic, drinking, mental health or substance use variables.

Methods: Perceived positive consequences of drinking were assessed using the PROMIS: Positive Consequences-Short Form.

Barriers to vaccination for coronavirus disease 2019 (COVID-19) control: experience from the United States.

To date, the United States (U.S.) has been the most heavily impacted country by the coronavirus disease 2019 (COVID-19).