Publications by authors named "R Ferrari"
Glomerular nephropathy resulting from the genetic defects in COL4A3/4/5 genes including the classical Alport syndrome (AS) is the second commonest hereditary kidney disease characterized by persistent haematuria progressing to the need of kidney replacement therapy, frequently associated with sensorineural deafness, and occasionally with ocular anomalies. Diagnosis and management of COL4A3/4/5 glomerulopathy is a great challenge due to its phenotypic heterogeneity, multiple modes of inheritance, variable expressivity, and disease penetrance of individual variants as well as imperfect prognostic and progression factors and scarce and limited clinical trials, especially in children. As a joint initiative of the European Rare Kidney disease reference Network (ERKNet), European Renal Association (ERA Genes&Kidney) and European Society for Paediatric Nephrology (ESPN) Working Group Hereditary Kidney Disorders, a team of experts including adult and paediatric nephrologists, kidney geneticists, audiologists, ophthalmologists and a kidney pathologist were selected to perform a systematic literature review on 21 clinically relevant PICO (Patient or Population covered, Intervention, Comparator, Outcome) questions.
View Article and Find Full Text PDFEffects of a 4-Week Detraining Period After 12 Weeks of Combined Training Using Different Weekly Frequencies on Health-Related Physical Fitness in Older Adults.
Int J Environ Res Public Health
October 2024
Background: Detraining refers to the decline in physical fitness that occurs after the cessation of exercise, compromising the adaptations resulting from regular exercise training. To understand how long the benefits acquired from an exercise program can be maintained, the present study evaluated the detraining effects of a 4-week exercise cessation period in older adults who performed combined training at various weekly frequencies for 12 weeks.
Methods: This randomized controlled trial assigned participants to one of two training programs: a combined training program twice a week (CT2) or four times a week (CT4) over a period of 12 weeks, followed by a four-week detraining period.
Article Synopsis
- * Interviews were conducted with 12 mothers from low socioeconomic backgrounds, highlighting that barriers to maternal presence are largely societal and institutional, while facilitators depend on personal and interpersonal circumstances.
- * Recommendations for hospitals include offering free or low-cost sibling support, reducing parking fees, and providing clear communication about available resources to help families during their hospital stays.
Importance: Colorectal cancer (CRC) screening is effective but remains underused in federally qualified health centers (FQHCs).
Objective: To assess the effectiveness of a centralized CRC screening outreach intervention involving mailed fecal immunochemical testing (FIT) outreach and patient navigation to colonoscopy after abnormal results of FIT.
Design, Setting, And Participants: A pragmatic randomized clinical trial was conducted, using intention-to-treat analysis.