Publications by authors named "R Farnoud"
Article Synopsis
- The study examines the occurrence and location of coronary artery disease (CAD) in adults with anomalous aortic origin of a coronary artery (AAOCA), which is not well documented.
- Researchers analyzed data from 390 patients, focusing on the presence of CAD through imaging techniques like coronary angiography.
- The findings revealed that CAD is more prevalent in the proximal segment of retroaortic AAOCA compared to other types of AAOCA, with no CAD found in the proximal segment of interarterial AAOCA, and the reasons for these differences remain unclear.
Anomalous aortic origin of the coronary arteries are congenital anomalies with many anatomical forms. Due to the varying risk of sudden death, these abnormalities must be classified accurately. There are still questions about the mechanism and individual risk of sudden death, the natural history of these abnormalities and the benefits of a surgical correction.
View Article and Find Full Text PDFTwo proteases cathepsin D (cath D) and urokinase plasminogen activator (uPA) are tissue markers associated with an increased risk of metastasis in breast cancer. We investigated whether cath D, the major aspartyl protease overexpressed by breast cancer cells can trigger a proteolytic cascade via activation of plasminogens at the extracellular pH measured in hypoxic tumors. The effects of the aspartyl protease inhibitor pepstatin on the plasminogen activator (PA) system were analysed by conditioning media of human MDA-MB231 breast cancer cells at pH 6.
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