M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells.

Glioblastoma (GB) is a very aggressive human brain tumor. The high growth potential and invasiveness make this tumor surgically and pharmacologically untreatable. Our previous work demonstrated that the activation of the M2 muscarinic acetylcholine receptors (M2 mAChRs) inhibited cell proliferation and survival in GB cell lines and in the cancer stem cells derived from human biopsies.

Learning to look with one eye: the use of head turn by normals and strabismics.

When asked to look through a tube, young children (normal, strabismic, monocularly enucleated) place it between the eyes, while older children turn the head or shut one eye. We videotaped 174 children (normals and strabismics, 2-17 yr of age) and 16 normal adults to find out when and why head turn occurs. In learning to look with one eye, children progressed through a sequence of four responses, categorized by age or amount of head turn.