Publications by authors named "R F Sing"
Introduction: Identifying patients who can be safely managed in lower-level trauma centers is critical to avoid overburdening level I centers. This study examines the transfer patterns and outcomes of blunt splenic injury (BSI) patients cared for at 2 regional level III trauma centers as compared to an associated level I center.
Methods: A retrospective cohort study was conducted including all trauma patients with BSI admitted to 2 level III trauma centers (TC3) and a level I center (TC1) between 2012 and 2022.
Article Synopsis
- - The study examined unexpected ICU admissions among trauma patients at a level 1 trauma center from 2019 to 2021, categorizing them into "bounce-backs" (previous ICU patients) and "upgrades" (new ICU admissions).
- - Out of 300 unplanned ICU transfers, 69% were bounce-backs and 31% were upgrades, with traumatic brain injuries and rib fractures being the most common injuries; respiratory distress was the leading cause for transfers.
- - The results indicated that many transfers occurred shortly after initial admission, suggesting that under-triage may be a significant issue, highlighting areas for improvement in trauma care.
In this work, we investigated the presence and function of TRPM8, a non-selective and cold-sensitive Ca-permeable ion channel in the primary microglia cell as well as in microglia cell line BV2. We demonstrate that primary microglia as well as BV2 express TRPM8 endogenously. Both pharmacological activation or inhibition of TRPM8 causes enhanced uptake of bacterial particles at early time points of infection.
View Article and Find Full Text PDFBackground: End-tidal carbon dioxide (ETCO) has previously shown promise as a predictor of shock severity and mortality in trauma. ETCO monitoring is non-invasive, real-time, and readily available in prehospital settings, but the temporal relationship of ETCO to systemic oxygen transport has not been thoroughly investigated in the context of hemorrhagic shock.
Methods: A validated porcine model of hemorrhagic shock and resuscitation was used in male Yorkshire swine (N = 7).
Background: Intercostal nerve cryoablation is an adjunctive measure that has demonstrated pain control, decrease in opioid consumption, and decrease in hospital length of stay (LOS) in patients who undergo surgical stabilization of rib fractures (SSRF).
Methods: SSRF patients from January 2015 to September 2021 were retrospectively compared. All patients received multimodal pain regimens post-operatively and the independent variable was intraoperative cryoablation.