Publications by authors named "R F Piper"
Peripheral Myelin Protein 22 (PMP22) and MPZ are abundant myelin membrane proteins in Schwann cells. The MPZ adhesion protein holds myelin wraps together across the intraperiod line. PMP22 is a tetraspan protein belonging to the Claudin superfamily.
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- Hippocampal sclerosis (HS) is a major cause of temporal lobe epilepsy (TLE) but can be hard to detect on MRI, leading to surgical delays, so researchers created open-source software to improve diagnosis.
- The study involved 365 participants, using the software HippUnfold to analyze MRI scans and develop a logistic regression model that accurately identifies and localizes HS.
- The classifier showed high accuracy in detecting HS in both initial and independent patient cohorts, proving effective for individual assessments by comparing patient data with normative growth patterns.
Objective: Evaluate the sensitivity and financial costs of Trans-Impedance Matrix recordings, Spread of Excitation functions, and x-rays in detecting cochlear implant tip foldovers.
Setting: Tertiary academic medical center.
Patients: 113 ears of 108 patients.
Interictal blood-brain barrier dysfunction in piriform cortex of people with epilepsy.
Ann Clin Transl Neurol
October 2024
Objective: The piriform cortex is considered to be highly epileptogenic. Its resection during epilepsy surgery is a predictor for postoperative seizure freedom in temporal lobe epilepsy. Epilepsy is associated with a dysfunction of the blood-brain barrier.
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- HD-PTP (or PTPN23) plays a key role in the formation of multivesicular bodies by aiding endosomal sorting complexes, which is important for cellular transport.
- Researchers created mice with reduced HD-PTP levels to study its physiological effects, discovering these mice displayed lipodystrophy and impaired signaling in white adipose tissue related to various pathways, including RAS/MAPK and PI3K/AKT.
- The study found that while EGF binding was normal, there was reduced signaling activation due to changes in cholesterol distribution within cells, suggesting a crucial role for HD-PTP in both signaling regulation and maintaining fat tissue health.