Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.
Material And Methods: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries.
Alzheimers Dement
December 2024
Background: Language impairment manifestations in patients with the semantic variant of primary progressive aphasia (S-PPA) include surface dysgraphia. Word and pseudoword dictation helps characterize errors in these patients' writing to better conduct their therapeutic strategies. Few studies have addressed written language in patients with dementia, and even fewer have done so in PPA.
View Article and Find Full Text PDFMultidrug resistance (MDR) is a major challenge in cancer research. Collateral sensitizers, compounds that exploit the enhanced defense mechanisms of MDR cells as weaknesses, are a proposed strategy to overcome MDR. Our previous work reported the synthesis of two novel Isoquinolinequinone (IQQ) N-oxides that induce collateral sensitivity in MDR ABCB1-overexpressing non-small cell lung cancer (NSCLC) and colorectal cancer cells.
View Article and Find Full Text PDFHealth Sci Rep
December 2024
Background And Aims: The current study aimed to compare the effects of 12 weeks of moderate versus high-intensity water aerobics on muscle strength, body composition, lipid profile, blood pressure, and quality of life in both adults and older adults.
Methods: Twenty-one women (65.19 ± 9.