Publications by authors named "R F Mottram"

Despite improved survival rates for childhood cancer, around 60% of survivors suffer lifelong health problems due to their treatment, including fertility issues which account for one third of these problems. Ovarian or testicular tissue cryopreservation can be offered to patients whose cancer treatment puts them at high risk of subsequent subfertility, but it presents unique challenges compared to standard methods of fertility preservation. We report the available information on the experiences of cancer survivors who preserved tissue for future fertility, to support the development of survivorship care informed by recipients' perspectives and experiences to identify future research priorities.

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  • The 53BP1-RIF1-shieldin pathway is crucial for maintaining genome stability by preventing the degradation of DNA ends at double-strand breaks (DSBs).
  • RIF1 is recruited to DSBs through interaction with phospho-53BP1 and is influenced by the methylation of histone H3 at lysine 4, mediated by SETD1A-BOD1L.
  • Impairing SETD1A or BOD1L disrupts RIF1's ability to localize to DSBs, leading to issues in DNA repair and potential therapeutic resistance in certain cancer cells, highlighting the pathway's clinical significance.
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  • This systematic review analyzed factors affecting attendance at breast cancer screening, focusing on patient-level characteristics across studies published between 1987 and 2019.
  • Out of nearly 20,000 studies reviewed, 66 were included, highlighting that higher socioeconomic status, income, home ownership, being non-immigrant, being married, and having medium education levels were linked to increased screening attendance, while previous false-positive results decreased likelihood of reattending.
  • The study concluded that women with lower socioeconomic status and immigrants showed lower attendance rates, suggesting that practical and psychological barriers may play a crucial role in screening uptake.
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We use remotely sensed ice velocities in combination with observations of surface elevation and glacier area change to investigate the dynamics of Hagen Bræ, North Greenland in high detail over the last 35 years. From our data, we can establish for the first time that Hagen Bræ is a surge-type glacier with characteristics of both Alaskan- and Svalbard-type surging glaciers. We argue that the observed surge was preconditioned by the glacier geometry and triggered by englacially stored meltwater.

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Objective: Clinical options for managing nonmetastatic prostate cancer (PCa) vary. Each option has side effects associated with it, leading to difficulty in decision-making. This study aimed to assess the relationship between patient involvement in treatment decision-making and subsequent decision regret (DR), and quantify the impact of health-related quality of life (HRQL) outcomes on DR.

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