Publications by authors named "R F Marta"
Elevated levels of damage-associated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis.
Front Immunol
October 2024
Article Synopsis
- * Two specific DAMPs, HMGB1 and S100A8/A9, were found to be elevated in MF patients and linked to higher systemic inflammation and adverse clinical outcomes, such as anemia and lower survival rates.
- * Monocytes in MF patients are hyperactivated and contribute to increased levels of S100A8/A9, while also showing a strong inflammatory response through Toll-like receptors TLR4 and TLR2, suggesting that DAMPs
Article Synopsis
- Correctly interpreting germline RUNX1 variants is crucial for diagnosing and managing FPD/AML (familial platelet disorder/acute myeloid leukemia).
- The study highlights two families with significant FPD/AML characteristics that have missense variants at a crucial residue (Gly168), which are often misclassified as variants of unknown significance (VUS).
- Evidence from computational analysis and observed platelet expression suggests these variants are likely pathogenic, indicating a need to revise RUNX1 classification guidelines to improve diagnostic accuracy.
Background: Multiple blood cell abnormalities participate in the development of inflammation in systemic lupus erythematosus (SLE). Although platelets have been suggested as one of these contributors through the release of their content during activation, there are limited specific data about their role as immune players in SLE.
Materials And Methods: Thirteen SLE patients were included.
Myelofibrosis (MF) is a clonal hematopoietic stem cell disorder classified among chronic myeloproliferative neoplasms, characterized by exacerbated myeloid and megakaryocytic proliferation and bone marrow fibrosis. It is induced by driver (//) and high molecular risk mutations coupled to a sustained inflammatory state that contributes to disease pathogenesis. Patient outcome is determined by stratification into risk groups and refinement of current prognostic systems may help individualize treatment decisions.
View Article and Find Full Text PDFIntroduction: Despite cultural, religious and legal constraints, alcohol and drug abuse is rising in the United Arab Emirates (UAE). Therefore, we aim to produce a scoping review to summarise available scientific literature on alcohol and substance dependence (ASD) in all ethnic and religious groups in the UAE to inform future scientific inquiries.
Methods And Analysis: Social work faculty from the UAE University will conduct the scoping review between March 2023 and February 2024.