Publications by authors named "R F Mancuso"
Objective: This study examines how age at death, sex, and socio-historical context relate to the frequency, location, and severity of Schmorl's nodes.
Materials: The sample comprised thoracic and lumbar vertebrae of 192 skeletons from two contemporary documented osteological collections from Spain, in Valladolid and Granada, both of which contain individuals who died during the second half of the 20th century.
Methods: Schmorl's nodes were recorded on the superior and inferior surfaces of vertebral bodies and their location was categorized in one of three areas: center, canal, and periphery.
Blood-based biomarkers are minimally invasive tools to detect the pathological changes of Alzheimer's Disease (AD). This meta-analysis aims to investigate the use of blood-derived p-tau isoforms (181, 217, 231) to predict conversion from mild cognitive impairment (MCI) to AD dementia (ADD). Studies involving MCI patients with data on blood p-tau isoforms at baseline and clinical diagnosis at follow-up (≥1 year) were included.
View Article and Find Full Text PDFNeuroinflammation in Alzheimer disease.
Nat Rev Immunol
December 2024
Article Synopsis
- Research highlights the significant role of immune processes in the development of Alzheimer's disease, which is the leading cause of dementia.
- Various studies indicate that both innate and adaptive immune responses contribute to the disease's pathology and are influenced by genetics and lifestyle factors.
- New therapeutic approaches targeting neuroinflammation are being explored in clinical settings, offering potential treatment options for Alzheimer's patients.
The major genetic risk factor for Alzheimer's disease (AD), APOE4, accelerates beta-amyloid (Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or astrocytes is debated. We express here the human APOE isoforms in astrocytes in an Apoe-deficient AD mouse model. This is not only sufficient to restore the amyloid plaque pathology but also induces the characteristic transcriptional pathological responses in Apoe-deficient microglia surrounding the plaques.
View Article and Find Full Text PDFDefining a parameter to select the best radiotherapy technique in patients with right breast cancer after conservative surgery: Evaluation of high doses and risk of radio-induced second tumors to the ipsilateral lung.
Phys Med
November 2024
Article Synopsis
- The study aimed to determine a useful parameter for choosing between 3D-CRT and VMAT techniques in adjuvant right breast radiation therapy, focusing on minimizing pneumonia risk to the ipsilateral lung (IL) from high doses.
- Analyzed treatment plans from twenty-five 3D-CRT and thirty-five VMAT techniques revealed that VMAT provides better dose conformity and less risk of toxicity to the IL compared to 3D-CRT under certain conditions.
- The Maximum Thickness of Ipsilateral Lung (MATIL) serves as an effective indicator for selecting the VMAT technique, which also appears to justify the use of VMAT to mitigate risks of induced cancer from radiation exposure.