Publications by authors named "R F Lams"
Article Synopsis
- Malignant cells grow not just from their own factors, but also from the environment around them, especially cells like monocytes and macrophages.
- In acute myeloid leukemia, certain macrophages help the cancer grow instead of fighting it, and their presence in the body is linked to how long mice survive in experiments.
- A specific protein called Growth factor independence 1 is important because it affects how these macrophages change; without it, they are less likely to support the cancer.
Epigenetic changes can contribute to development of acute myeloid leukemia (AML), a malignant disease of the bone marrow. A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI1(36N)) instead of a serine at position 36 (GFI1(36S)), which is associated with de novo AML in humans. However, how GFI1(36N) predisposes to AML is poorly understood.
View Article and Find Full Text PDFGenetic and epigenetic aberrations contribute to the initiation and progression of acute myeloid leukemia (AML). GFI1, a zinc-finger transcriptional repressor, exerts its function by recruiting histone deacetylases to target genes. We present data that low expression of GFI1 is associated with an inferior prognosis of AML patients.
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