Publications by authors named "R F Kokelaar"
Article Synopsis
- Colorectal anastomotic devices have been used for almost 100 years, with stapled methods being most common, despite a significant leak risk of up to 20%.
- A systematic review and meta-analysis explored newer anastomotic devices, analyzing 18 studies from the last decade, which included 955 anastomoses and focused on non-stapled methods.
- The findings indicated a pooled complication rate of 9.7% for human studies, but new compression mechanisms showed a much lower leak rate of 3.3%, suggesting that these novel technologies could improve surgical outcomes.
Meta-analysis of the prognostic value of CpG island methylator phenotype in rectal cancer.
Int J Colorectal Dis
August 2018
Purpose: The pathological and prognostic importance of CpG island methylator phenotype (CIMP) in rectal cancer, as a sub-population of colorectal cancer, is unknown. A meta-analysis was preformed to estimate the prognostic significance of CIMP in rectal cancer.
Methods: A systematic search was performed of PubMed, Embase, MEDLINE, PubMed Central, and Cochrane electronic databases for articles pertaining to CIMP and rectal cancer.
Inflammatory cell ratios predict major septic complications following rectal cancer surgery.
Int J Colorectal Dis
July 2018
Introduction: The inflammatory response is known to have an important role in tumourigenesis and the response to treatment. Previous studies have demonstrated that inflammatory cell ratios such as the neutrophil-to-lymphocyte ratio (NLR) can predict survival and recurrence following surgery for various cancers. The objective of this study was to demonstrate if pre-operative NLR has a role in predicting post-operative septic complications in patients undergoing rectal cancer surgery.
View Article and Find Full Text PDFPurpose: DNA hypermethylation in gene promoter regions (CpG islands) is emerging as an important pathway in colorectal cancer tumourigenesis. Whilst genetic mutations have been associated with extramural vascular invasion (EMVI) in rectal cancer, no such association has yet been made with epigenetic factors.
Methods: 100 consecutive neoadjuvant-naïve patients undergoing curative surgery for rectal were classified according to the presence or absence of EMVI on histopathological examination.