The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas.

Background: Cancer-associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro-tumourigenic or anti-tumourigenic functions. Their inherent phenotypic and functional diversity allows for the subdivision of CAFs into various subpopulations. While several classification systems have been suggested for different cancer types, a unified molecular classification of CAFs on a single-cell pan-cancer scale has yet to be established.

A new clustering method based on multipartite networks.

The clustering problem is one of the most studied and challenging in machine learning, as it attempts to identify similarities within data without any prior knowledge. Among modern clustering algorithms, the network-based ones are some of the most popular. Most of them convert the data into a graph in which instances of the data represent the nodes and a similarity measure is used to add edges.

MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5.

MLK4, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, has been implicated in cancer progression. However, its role in lung adenocarcinoma has not been characterized. Here, we showed that MLK4 was overexpressed in a significant subset of lung adenocarcinoma, associated with a worse prognosis, and exerted an oncogenic function in vitro and in vivo.

A game-theoretic model for the classification of selected oil companies' price changes.

One of the essential properties of a machine learning model is to be able to capture nuanced connections within data. This ability can be enhanced by considering alternative solution concepts, such as those offered by game theory. In this article, the Nash equilibrium is used as a solution concept to estimate probit parameters for the binary classification problem.

Analgesic Effect of Ropivacaine Pumped in the Sub Rectus Abdominis Muscle Sheath after Abdominoplasty.

Background: Abdominoplasty is a major surgical procedure in plastic surgery. It removes excess skin and fat, tightens abdominal muscles and fascia, restores normal abdominal anatomy and reshapes the distorted abdominal contour. According to the statistics released annually by International Society of Aesthetic Plastic Surgery (ISAPS) in 2020, there are more than 900, 000 abdominal wall plastic surgeries performed every year worldwide.