Publications by authors named "R F Corder"
Article Synopsis
- The study focuses on an innovative thermosensitive quadpolymer designed for injection to deliver anti-fibrotic drugs, specifically targeting uterine fibroids while potentially preserving fertility.
- The quadpolymer functions as an injectable solution at room temperature and transforms into a stable gel at body temperature, allowing for sustained release of the drug pirfenidone.
- Results showed that the pirfenidone-loaded quadpolymer effectively inhibited fibroid cell proliferation, indicating its potential as a localized treatment option for uterine fibroid therapy.
Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium sp.
View Article and Find Full Text PDFInsecticide resistance (IR) poses a significant global challenge to public health and welfare. Here, we develop a locally-acting unitary self-eliminating allelic-drive system, inserted into the Drosophila melanogaster yellow (y) locus. The drive cassette encodes both Cas9 and a single gRNA to bias inheritance of the favored wild-type (1014 L) allele over the IR (1014 F) variant of the voltage-gated sodium ion channel (vgsc) target locus.
View Article and Find Full Text PDFBackground: In the Peruvian Amazon, Plasmodium vivax malaria transmission is maintained due to the high frequency of recurrences. By understanding the recurrence rates of submicroscopic and asymptomatic cases, we can develop informed strategies to prevent transmission more efficiently and disrupt the silent transmission cycle.
Methods: A three-year, population-based cohort study was conducted in two sites, Cahuide and Lupuna, within the Loreto region in Peru from 2013 to 2015.
Understanding the rheology of minipig and human skin is crucial for enhancing drug delivery methods, particularly for injections. Despite many studies on skin's viscoelasticity, especially the subcutaneous layer, comparative analyses across different clinical sites are scarce, as is data on the impact of hydration or lipid levels. This study employs shear rheology and lipid analysis to evaluate viscoelasticity and lipid content across three anatomical locations-breast, belly, and neck and three different depth layers in Yucatan minipigs.
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