Publications by authors named "R F Cook"
Cavoatrial Bypass for Cardiac Complications From Rosai-Dorfman Disease.
Ann Thorac Surg Short Rep
September 2024
Rosai-Dorfman disease (RDD) is a nonmalignant disease of histiocyte proliferation. RDD usually presents with painless cervical lymphadenopathy, although extranodal involvement can occur. Cardiac involvement was reported in <0.
View Article and Find Full Text PDFBackground/objectives: Narcolepsy is a chronic neurologic disorder associated with substantial challenges that affect the social, emotional, and financial quality-of-life domains. A social listening analysis and structured survey were conducted to better understand the candid perspective of people with narcolepsy (PWN) and their experience with twice-nightly sodium oxybate (SXB).
Methods: To characterize conversations and experiences in narcolepsy communities where SXB was mentioned, a social media analysis was conducted from August 2011 to October 2022.
Background: There is minimal literature on the outcomes of acute traumatic subdural hematoma (SDH) in patients 90 years of age or older. This study aims to characterize the presentation and acute outcomes of patients in this population, particularly for surgical candidates.
Methods: Patients 90 years of age or older with acute SDH between 2013-2023 were analyzed (n = 117).
The anti-apoptotic protein myeloid cell leukemia-1 (Mcl-1) contributes to the pathophysiology of acute myeloid leukemia (AML) and certain B-cell malignancies. Tumor dependence on Mcl-1 is associated with resistance to venetoclax. Voruciclib, an oral cyclin-dependent kinase (CDK) inhibitor targeting CDK9, indirectly decreases Mcl-1 protein expression and synergizes with venetoclax in preclinical models.
View Article and Find Full Text PDFArticle Synopsis
- Soil organic matter (SOM) is crucial for reducing greenhouse gas emissions and supporting global climate, carbon cycles, and biodiversity.
- Coastal wetland soils, which constitute one-third of SOM, are eroding rapidly due to rising sea levels, highlighting a gap in research on carbon sequestration in these areas compared to upland soils.
- Using solid-state nuclear magnetic resonance (ssNMR), the study reveals that some molecular structures in wetland soils have been preserved for over 1,000 years, but these structures are declining in abundance as decomposition and repolymerization processes occur, making coastal wetland SOM increasingly vulnerable to environmental changes.