Publications by authors named "R F Coghlan"
How can palliative care framings advance humanitarian discourse? The imperative for palliative care in humanitarian settings is increasingly urgent. Recent efforts by health and humanitarian organizations demonstrate increasing attention to the issue. Yet palliative care is still not adequately formally considered or enacted by humanitarian agencies in rhetoric, policy, research, or practice.
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- Collagen X biomarker (CXM) has been studied as an indicator of growth velocity in children with impaired kidney function, focusing on its correlation with actual growth measurements.
- The study utilized data from children aged 2 to 16 enrolled in the Chronic Kidney Disease in Children (CKiD) study, employing various statistical models to assess the relationship between CXM levels and growth velocity.
- Results showed a stronger correlation of CXM with growth in females than in males, with specific increases in CXM levels correlating to higher growth rates, suggesting its potential role in monitoring growth in pediatric chronic kidney disease while indicating the need for further research.
Article Synopsis
- Diastrophic dysplasia (DTD) is caused by mutations in the SLC26A2 gene, affecting sulfate uptake and glycosaminoglycan (GAG) sulfation, and it may benefit from pharmacological treatments as studied in an animal model.
- In identifying non-invasive biomarkers for DTD, research focused on urinary GAG sulfation and blood levels of collagen X marker (CXM), which are linked to the severity of the condition and growth metrics.
- Results indicated that DTD patients exhibit undersulfated urinary GAGs and lower than normal CXM levels, suggesting both biomarkers can help evaluate treatment effectiveness and the disorder's metabolism and ossification processes.
Objective: To advance the understanding of how alterations in exercise speed and grade (flat vs 17° incline or decline) affect the quality of tendon healing, and to determine if a biomarker relationship exists between serum levels of a ColX breakdown product (CXM) and animals exposed to treadmill running protocols.
Animals: 35 male mice (C57BL/6J), 8 weeks of age.
Procedures: Mice were preconditioned on a treadmill for 14 days.