Publications by authors named "R F Bishop"
Objective: To describe indications for and demonstrate the technique to perform a transtracheal aspirate in horses. Transtracheal aspirate is indicated to collect samples for cytology and bacteriologic culture in cases of suspected pneumonia or other lower respiratory tract disease.
Animals: 1 healthy university-owned horse was used for demonstration purposes.
Multiple myeloma (MM) patients are often refractory to targeted therapies including proteasome inhibitors (PIs). Here, analysis of RNA sequencing data derived from 672 patients with newly diagnosed or relapsed/refractory disease identified the acid ceramidase, ASAH1, as a key regulator of PI resistance. Genetic or pharmacological blockade of ASAH1 remarkably restored PI sensitivity and protected mice from resistant MM progression in vivo.
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- - The study aimed to determine the reference interval (RI) for fecal calprotectin (fCP) levels and fCP:protein ratios in healthy horses to assess their potential for diagnosing intestinal inflammation in horses with colic and colitis.
- - Fecal samples were analyzed from 103 healthy horses and 28 horses with intestinal conditions, revealing that colitis cases had significantly higher fCP levels and fCP:protein ratios compared to healthy horses and colic cases.
- - The findings suggest that elevated fCP and fCP:protein ratios could be indicative of colitis but further research is necessary to develop reliable diagnostic tests for equine intestinal inflammation.
Introduction: Increasing overdose deaths and criminal legal involvement among women necessitate women-specific solutions to curb the adverse consequences of substance use disorders (SUDs). The current study is the pre-implementation phase of an implementation science study that works with various stakeholders-affected women, criminal legal professionals, and SUD treatment professionals-to identify and address high-priority needs for criminal-legal involved women with SUDs.
Methods: This study uses semi-structured interviews (N = 42) administered in 2022 to women with a history of SUD and criminal legal involvement (n = 20), SUD treatment professionals (n = 12), and criminal legal professionals (n = 10).