Publications by authors named "R Ewen"
Objectives: In patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD), the response to treatment is evaluated based on microbiological, clinical, and radiological data. However, little is known about the dynamics of CT findings. The aim of this study was to evaluate CT changes in NTM-PD in order to define radiological criteria for treatment success.
View Article and Find Full Text PDFBackground: Primary ciliary dyskinesia (PCD) is a rare genetic disorder caused by the malfunction of motile cilia and a specific etiology of adult bronchiectasis of unknown prevalence. A better understanding of the clinical phenotype of adults with PCD is needed to identify individuals for referral to diagnostic testing.
Research Question: What is the frequency of PCD among adults with bronchiectasis; how do people with PCD differ from those with other etiologies; and which clinical characteristics are independently associated with PCD?
Study Design And Methods: We investigated the proportion of PCD among the participants of the Prospective German Non-CF-Bronchiectasis Registry (PROGNOSIS) study; applied multiple imputation to account for missing data in 64 (FEV), 58 (breathlessness), 26 (pulmonary exacerbations), and two patients (BMI), respectively; and identified predictive variables from baseline data using multivariate logistic regression analysis.
Article Synopsis
- - Whole-exome sequencing helps diagnose primary ciliary dyskinesia (PCD) but often uncovers variants of uncertain significance (VUS), complicating results in about 30% of patients.
- - The study focused on 16 adults with bronchiectasis and inconclusive whole-exome sequencing results, using transmission electron microscopy (TEM) and specialized software to analyze ciliary structures.
- - Results showed that while eight patients had normal ciliary structure, six exhibited notable defects linked to VUS, and one had a defect confirming clinical relevance, indicating that TEM can effectively clarify genotype-phenotype correlations in PCD cases.
Background: Oxygen (O2) therapy is one of the most commonly applied medications in German hospitals and rescue services. Both hypoxemia and hyperoxemia can be associated with complications. There is currently a lack of reliable data on the use, documentation and surveillance of O2-therapy in German hospitals.
View Article and Find Full Text PDFBackground: Oxygen (O2) therapy is one of the most commonly applied medications in German hospitals and rescue services. Both hypoxemia and hyperoxemia can be associated with complications. There is currently a lack of reliable data on the use, documentation and surveillance of O2-therapy in German hospitals.
View Article and Find Full Text PDF