SIMONE: a realistic neural network simulator to reproduce MEA-based recordings.

Contemporary multielectrode arrays (MEAs) used to record extracellular activity from neural tissues can deliver data at rates on the order of 100 Mbps. Such rates require efficient data compression and/or preprocessing algorithms implemented on an application specific integrated circuit (ASIC) close to the MEA. We present SIMONE (Statistical sIMulation Of Neuronal networks Engine), a versatile simulation tool whose parameters can be either fixed or defined by a probability distribution.

Wavelet-based scale-dependent detection of neurological action potentials.

We study different wavelet-based algorithms for the detection of neurological action potentials recorded using micro-electrode arrays (MEA). We plan to develop a new family of ASIC-embedded low power algorithms close to the recording sites. We use the wavelet theory, not for previous-to-the-detection denoising stage (as it is usually used for) but for the detection itself.

Development and application of immunoaffinity chromatography for the determination of the triazinic biocides in seawater.

The development of an immunoaffinity chromatography (IAC) procedure for the selective extraction of the anti-fouling agent Irgarol 1051 [2-(tert.-butylamino)-4-(cyclopropylamino)-6-(methylthio)-1,3,5-triazine] from seawater is described. The anti-Irgarol 1051 antibodies were covalently bound to agarose-based beads support.

Localization and quantification of TXB2 in human healthy and inflammatory gingival mucosa.

We conducted a study to localize and quantify the thromboxane B2 (TXB2) in human gingival tissue obtained from clinically healthy sites and patients with gingivitis and periodontitis. Human gingival samples were assayed for TXB2 by immunofluorescence on slides and enzyme-immunoassay (EIA). We found that concentrations of TXB2 in gingivitis sites are at mean 10-fold higher than in the healthy sites and histologically show a consistently intracytoplasmic staining with a significant increase in gingivitis.