THE STING AGONIST VB-85247 INDUCES DURABLE ANTITUMOR IMMUNE RESPONSES BY INTRAVESICAL ADMINISTRATION IN A NON-MUSCLE INVASIVE BLADDER CANCER.

Bacillus Calmette-Guerin (BCG) is the current standard of care for non-muscle invasive bladder cancer (NMIBC), but recurrence is common. Additional therapeutic options are a major unmet medical need for treating unresponsive patients. Stimulator of Interferon Genes (STING) plays a central role in mounting innate and adaptive immune responses to tumor cells, and activation of STING is a promising immunotherapeutic approach.

SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy.

Background: Cytokines have been promising cancer immunotherapeutics for decades, yet only two are licensed to date. Interleukin-12 (IL-12) is a potent regulator of cell-mediated immunity that activates NK cells and interferon-γ (IFNγ) production. It plays a central role in multiple pathways that can enhance cancer cell death and modify the tumor microenvironment (TME).

Evaluation of polyaryletherketone materials as post-core abutments for removable partial dentures: A finite element analysis.

Objective: The purpose was to compare the biomechanical behavior of single-piece post-core restorations made from polyaryletherketone materials with fiber post-core restorations when serving as abutments for RPD using finite element analysis (FEA).

Methods: Phantom maxillary central incisor and mandibular second premolar were trimmed 1-mm coronally to cemento-enamel junction; root canals were enlarged and the teeth were scanned. Data was transferred to a solid modeling software.

Effect of different sintering procedures on marginal and internal fit, color, and fracture load of monolithic zirconia fixed partial prostheses.

Aim: The aim of the present in vitro study was to investigate the effects of different sintering procedures on the fit, color parameters, and fracture load of monolithic fixed partial prostheses (FPPs).

Materials And Methods: A metal master model was scanned and FPPs were designed. Groups were created by fabricating FPPs using four different sintering procedures (n = 10): Prettau-Standard (PST); Prettau-Slow (PSL); Ice-Speed (ISP); Ice-Standard (IST).

SON-1210 - a novel bifunctional IL-12 / IL-15 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy.

Background: The potential synergy between interleukin-12 (IL-12) and IL-15 holds promise for more effective solid tumor immunotherapy. Nevertheless, previous clinical trials involving therapeutic cytokines have encountered obstacles such as short pharmacokinetics, limited tumor microenvironment (TME) targeting, and substantial systemic toxicity.

Methods: To address these challenges, we fused single-chain human IL-12 and native human IL-15 in onto a fully human albumin binding (FAB) domain single-chain antibody fragment (scFv).