Multisite Is Superior to Single-Site Intratumoral Chemotherapy to Retard the Outcomes of Pancreatic Ductal Adenocarcinoma in a Murine Model.

Introduction: Locally advanced unresectable pancreatic cancer (LAPC) has a dismal prognosis, with intratumoral therapies showing limited benefits. We assume that the dense stroma within these tumors hampers drug dispersion.

Aim: This study explores the efficacy of multisite intratumoral injections in improving a drug's distribution while minimizing its side effects.

The Older Adults With Rectal Cancer-Does Age Matter?: A Single-center Experience.

Objectives: Oncological treatments of older patients have many unresolved questions mainly because of the fact that these patients were not eligible to be included in most clinical trials. The aim of this study was to evaluate the treatment approach to localized rectal cancer in the older population, including complication rates and overall survival in patients treated with curative intent.

Materials And Methods: A retrospective review of patients older than 80 years old (group A) who were treated for clinical stages II to III rectal cancer.

Rucaparib Monotherapy in Patients With Pancreatic Cancer and a Known Deleterious Mutation.

Purpose: Pancreatic cancer has a poor prognosis and limited treatment options. Approximately 9% of pancreatic cancers harbor a germline or somatic or () mutation. Because poly (ADP-ribose) polymerase inhibitors have significant activity in -mutant ovarian and breast cancers, RUCAPANC investigated the efficacy and safety of rucaparib in -mutant pancreatic cancer.

Mutant Circulating Tumor DNA Is an Accurate Tool for Pancreatic Cancer Monitoring.

Background: Many new pancreatic cancer treatment combinations have been discovered in recent years, yet the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains grim. The advent of new treatments highlights the need for better monitoring tools for treatment response, to allow a timely switch between different therapeutic regimens. Circulating tumor DNA (ctDNA) is a tool for cancer detection and characterization with growing clinical use.

Modification of initial therapy in early and advanced Hodgkin lymphoma, based on interim PET/CT is beneficial: a prospective multicentre trial of 355 patients.

This multicentre study evaluated 5-year progression-free (PFS) and overall survival (OS) in early and advanced Hodgkin lymphoma (HL), where therapy was individualized based on initial prognostic factors and positron emission tomography-computed tomography performed after two cycles (PET-2). Between September 2006 and August 2013, 359 patients aged 18-60 years, were recruited in nine Israeli centres. Early-HL patients initially received ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) ×2.