A retrospective comparison of Coronal Plane Alignment of the Knee.

Background: Unicompartmental arthritic degeneration is treated by unicompartmental knee arthroplasties (UKA). The two current standards are mechanical alignment, where knee placement is perpendicular to the leg's mechanical axis and kinematic alignment, that consists of aligning the knee with the angles specific to the patient's innate bone structure. The purpose of this study was to compare knee alignment between mechanical and kinematic UKA.

Small Molecule Intervention in a Protein Kinase C-Gli Transcription Factor Axis.

Aberrations in the Hedgehog (Hh) signaling pathway are responsible for a broad range of human cancers, yet only a subset rely on the activity of the clinical target, Smoothened (Smo). Emerging cases of cancers that are insensitive to Smo-targeting drugs demand new therapeutic targets and agents for inhibition. As such, we sought to pursue a recently discovered connection between the Hedgehog pathway transcription factors, the glioma-associated oncogene homologues (Glis), and protein kinase C (PKC) isozymes.

Evaluation of Thermal Properties of 3D Spacer Technical Materials in Cold Environments using 3D Printing Technology.

Novel materials have been recently developed for coping with various environmental factors. Generally, to improve the thermal comfort to humans in cold environments, securing an air layer is important. Therefore, this study analyzed the thermal properties of 3D spacer technical materials, 3D printed using thermoplastic polyurethane, according to the structural changes.

The vaporization rate of ice at temperatures near its melting point.

The first study of free vaporization kinetics of ice at temperatures near its melting point is reported. The experimental approach employed is based on a unique combination of thermal desorption spectroscopy, microcalorimetry, and time-of-flight mass spectrometry, making it possible to overcome challenges associated with the introduction of volatile solids into a high vacuum environment. Measurements of the vaporization rate of polycrystalline ice demonstrate that the vaporization kinetics deviate dramatically from those predicted by a simple mobile precursor mechanism.