Publications by authors named "R Elliott Overman"
Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric proteins is an attractive strategy for therapeutics. Focusing on HER2, a frequently overexpressed receptor in breast cancer, this study addresses some limitations of conventional targeting moieties by harnessing the potential of these scaffolds.
View Article and Find Full Text PDFBackground: Shorter prophylactic vaccine schedules may offer more rapid protection against Ebola in resource-limited settings.
Methods: This randomized, observer-blind, placebo-controlled, phase 2 trial conducted in 5 sub-Saharan African countries included people without human immunodeficiency virus (HIV) (PWOH, n = 249) and people with HIV (PWH, n = 250). Adult participants received 1 of 2 accelerated Ebola vaccine regimens (MVA-BN-Filo, Ad26.
Article Synopsis
- The study aimed to evaluate the effectiveness of MRI in predicting ovarian cancer in young patients compared to other diagnostic tools like ultrasounds and tumor markers.
- Out of 1,053 patients, 10% were found to have malignancies, revealing MRI's sensitivity and specificity to be 60% and 94% respectively, while ultrasound was less sensitive but more specific.
- The results suggest that MRI shows better sensitivity in ambiguous cases compared to ultrasound, and both MRI and tumor markers tend to agree, indicating that a combined approach could optimize preoperative assessment.