Publications by authors named "R Edupuganti"
Repressor element-1 silencing transcription factor (REST) is required for the formation of mature neurons. REST dysregulation underlies a key mechanism of neurodegeneration associated with neurological disorders. However, the mechanisms leading to alterations of REST-mediated silencing of key neurogenesis genes are not known.
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- Triple-negative breast cancer (TNBC) is associated with high relapse and metastasis rates due to the presence of cancer stem-like cells (CSCs) that promote tumor growth, with MELK being a key protein involved in maintaining these cells.
- The study revealed that high levels of MELK expression correlate with worse overall survival and increased risk of metastasis in breast cancer patients.
- Experimenting with MELK knockdown and inhibitor treatments showed reduced invasiveness and metastasis in TNBC cells, highlighting MELK as a significant driver of tumor aggressiveness and the metastatic process.
methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function in , which occurs solely during early meiosis. Here, we perform a multifaceted analysis of the m6A reader protein Pho92/Mrb1.
View Article and Find Full Text PDFClinical Study of Hepatic Dysfunction in Dengue Patients in a Tertiary Care Center.
J Assoc Physicians India
April 2022
Dengue is a mosquito-borne virus and the primary cause of arthropod-borne infectious disease in the world. Dengue fever is caused by any of 4 distinct serotypes of single-stranded RNA viruses of the genus Flavivirus. Infection by one serotype results in lifelong immunity to that serotype but not to others.
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