Denver pain authenticity stimulus set (D-PASS).

We introduce the Denver Pain Authenticity Stimulus Set (D-PASS), a free resource containing 315 videos of 105 unique individuals expressing authentic and posed pain. All expressers were recorded displaying one authentic (105; pain was elicited via a pressure algometer) and two posed (210) expressions of pain (one posed expression recorded before [posed-unrehearsed] and one recorded after [posed-rehearsed] the authentic pain expression). In addition to authentic and posed pain videos, the database includes an accompanying codebook including metrics assessed at the expresser and video levels (e.

Shear stress upregulates regeneration-related immediate early genes in liver progenitors in 3D ECM-like microenvironments.

The role of fluid stresses in activating the hepatic stem/progenitor cell regenerative response is not well understood. This study hypothesized that immediate early genes (IEGs) with known links to liver regeneration will be upregulated in liver progenitor cells (LPCs) exposed to in vitro shear stresses on the order of those produced from elevated interstitial flow after partial hepatectomy. The objectives were: (1) to develop a shear flow chamber for application of fluid stress to LPCs in 3D culture; and (2) to determine the effects of fluid stress on IEG expression in LPCs.

In-depth clinico-pathological examination of RNA foci in a large cohort of C9ORF72 expansion carriers.

A growing body of evidence suggests that a loss of chromosome 9 open reading frame 72 (C9ORF72) expression, formation of dipeptide-repeat proteins, and generation of RNA foci contribute to disease pathogenesis in amyotrophic lateral sclerosis and frontotemporal dementia. Although the levels of C9ORF72 transcripts and dipeptide-repeat proteins have already been examined thoroughly, much remains unknown about the role of RNA foci in C9ORF72-linked diseases. As such, we performed a comprehensive RNA foci study in an extensive pathological cohort of C9ORF72 expansion carriers (n = 63).

Use of omeprazole in the management of giant duodenal ulcer: results of a prospective study.

Background: Giant duodenal ulcer (GDU) is generally thought to require surgical intervention. Proton pump inhibitors have beneficial effects in peptic ulcer disease, but their role in GDU disease is unknown. We examined the use of omeprazole in GDU management.

Does use of the Coloscreen Self-Test improve patient compliance with fecal occult blood screening?

Occult blood-screening methods which do not require stool manipulation have been devised in an attempt to improve patient compliance with fecal occult blood testing. We performed a randomized, prospective study comparing patient compliance with the Coloscreen Self Test, a fecal occult blood detection method which does not require stool manipulation, and standard guaiac-impregnated cards in a VA clinic and a university-based private practice to determine whether the Coloscreen Self-Test would improve patient compliance with fecal occult blood testing. Overall, there was no significant difference in compliance between the two tests, with a compliance of 71% (105/147) for the guaiac cards and 60% (88/136) for the Coloscreen Self-Test (p = 0.