Effects of chronic naltrexone treatment in rats on place preference and locomotor activation after acute administration of cocaethylene or ethanol plus cocaine.

When cocaine and ethanol are taken together a cocaine metabolite called cocaethylene is produced. Investigators have determined that cocaine, ethanol, and cocaethylene all produce a conditioned place preference when administered intraperitoneally. On the basis of the moderate success of naltrexone at attenuating the rewarding effects of ethanol and cocaine administered independently, we examined the ability of chronic naltrexone treatment (administered by means of subcutaneous implant across 6 days) to reduce the preference and motor-stimulating effects resulting from intraperitoneal administration of cocaethylene (Experiment 1) and the co-administration of ethanol with cocaine (Experiment 2) in outbred rats.

Effects of dietary lead and/or dimercaptosuccinic acid exposure on regional serotonin and serotonin metabolite content in rainbow trout (Oncorhynchus mykiss).

The lead (Pb) chelator, meso-2,3-dimercaptosuccinic acid (DMSA) may be effective in reversing some of the adverse effects of Pb exposure. Pb-induced behavioral deficits observed in fish are due to disruptions in the integrative functioning of the medulla, cerebellum, and optic tectum. Pb exposure increased serotonin (5-HT) content in all three brain regions without an effect on 5-hydroxy-3-indoleacetic acid (5-HIAA).

Effects of the selective mu(1)-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats.

Administration of the non-selective opioid receptor antagonists, naloxone and naltrexone, attenuate the rewarding effects of cocaine. The relative contributions of specific opioid receptor subtypes that underlie this effect have not been well characterized. Administration of 20.

Effects of cocaine and putative atypical antipsychotics on rat social behavior: an ethopharmacological study.

The effects of cocaine, amperozide, clozapine, olanzapine and cocaine/atypical antipsychotic combinations on aggression, affiliation and defensive behaviors was examined. Acute cocaine (30.0 mg/kg) decreased basal aggression and affiliation yet increased basal defense.

Acute effects of amperozide and paroxetine on social cohesion in male conspecifics.

The effects of acute administration of the selective 5-hydroxytrypamine (5-HT; serotonin) uptake inhibitor, paroxetine, and the potent 5-HT(2A) receptor antagonist, N-ethyl-4-[4',4'-bis(rho-flourophenyl)butyl]-1-piperazinecarboxamide (amperozide) on social cohesion was determined by using a tether paradigm, in which the movement of one of a pair of rats was restricted to one-half of an observation chamber. Administration of 0.1mg/kg paroxetine, 1.