Plasma 5-HIAA activity indicative of serotonergic disturbances in cognitively impaired, elderly patients experiencing postoperative delirium.

Objectives: Delirium frequently arises in older demented and non-demented patients in postoperative, clinical settings. To date, the underlying pathophysiological mechanisms remain poorly understood. Monoamine neurotransmitter alterations have been linked to delirium and cognitive impairment.

Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study.

Background: Melatonin plays a major role in maintaining circadian rhythm. Changes in melatonin metabolism might lead to circadian rhythm disturbances which are often observed in delirious patients.

Aim: To assess if high morning plasma melatonin concentrations were associated with delirium.

Variability of Delirium Motor Subtype Scale-Defined Delirium Motor Subtypes in Elderly Adults with Hip Fracture: A Longitudinal Study.

Objectives: To examine changes in motor subtype profile in individuals with delirium.

Design: Observational, longitudinal study; substudy of a multicenter, randomized controlled trial.

Setting: Departments of surgery and orthopedics, Academic Medical Center and Tergooi Hospital, the Netherlands.

Preoperative CSF Melatonin Concentrations and the Occurrence of Delirium in Older Hip Fracture Patients: A Preliminary Study.

Background: Delirium is characterized by disturbances in circadian rhythm. Melatonin regulates our circadian rhythm. Our aim was to compare preoperative cerebrospinal fluid (CSF) melatonin levels in patients with and without postoperative delirium.

Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture.

Objectives: To assess the association between serum S100B levels (a marker of brain damage), delirium, and subsequent cognitive decline.

Design: Substudy of a multicenter randomized controlled trial.

Setting: Surgical, orthopedic, and trauma surgery wards of two teaching hospitals.