Publications by authors named "R E Safford"
Objective: To determine the prevalence of portopulmonary hypertension in patients referred for liver transplant evaluation.
Methods: Medical records were reviewed for 986 consecutive patients referred for liver transplant evaluation who were screened for pulmonary hypertension with echocardiography from February 1, 2021, to January 31, 2022, across 3 liver transplant centers.
Results: Of 934 patients eligible for analysis, mean (SD) age was 57 (11) years, 558 (59.
Article Synopsis
- Trade is a major threat to wild bird species, often occurring secretly and lacking proper monitoring, which complicates the understanding of which species are under threat.
- The study analyzed seven global data sets to create a trade prevalence score for bird species, identifying those at high risk and validating the data through literature and surveys.
- Results showed a strong agreement among data sets regarding trade prevalence, with 45.1% of all birds and 36.7% of threatened species receiving scores of 1 or more, highlighting the high risk of certain groups like Falconiformes and Psittaciformes in trade.
Patients with atrial fibrillation not associated with other cardiac conditions require different individualized treatment strategies. However, in all patients it is critical to address modifiable risk factors, assess stroke risk, minimize atrial fibrillation burden, and identify the patient's individual goals of care.
View Article and Find Full Text PDFThe Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used to justify exposure-based waiving when conducting a skin sensitisation risk assessment. This study aimed to update the published DST values by expanding the size of the Local Lymph Node Assay dataset upon which they are based, whilst assigning chemical reactivity using an in silico expert system (Derek Nexus). The potency values within the expanded dataset fitted a similar gamma distribution to that observed for the original dataset.
View Article and Find Full Text PDFSkin sensitization evaluation is a key part of the safety assessment of ingredients in consumer products, which may have skin sensitizing potential. The dermal sensitization threshold (DST) concept, which is based on the concept of the thresholds of toxicological concern, has been proposed for the risk assessment of chemicals to which skin exposure is very low level. There is negligible risk of skin sensitization if a skin exposure level for the substance of interest was below the reactive DST which would protect against 95% of protein-reactive chemicals.
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