Outcomes and Impact of Device Iterations in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.

Background: The PASCAL P10 system for mitral valve transcatheter edge-to-edge repair has undergone iterations, including introduction of the narrower Ace implant and the Precision delivery system.

Objectives: The study sought to evaluate outcomes and the impact of PASCAL mitral valve transcatheter edge-to-edge repair device iterations.

Methods: The REPAIR (REgistry of PAscal for mltral Regurgitation) study is an investigator-initiated, multicenter registry including consecutive patients with mitral regurgitation (MR) treated from 2019 to 2024.

Genetic Diversity and Expanded Phenotypes in Dystonia: Insights from Large-Scale Exome Sequencing.

Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (~25%) and the identification of several disease-linked genes, the etiology in most patients remains elusive. Moreover, understanding the correlations between clinical manifestation and genetic variants has become increasingly complex.

To err is human: Differences in performance monitoring ERPs during interactions with human co-actors and machines.

In interactive tasks, agents often aim at eliciting a certain response from their partner. Not accomplishing this goal calls for adjusting behavior on the fly. Previous research suggests that such adjustments differ when interacting with a machine or with a fellow human agent.

Observation inflation as source confusion: Symmetrical conflation of memories based on action performance and observation.

People often cannot remember the source of their memories despite recalling other elements of a remembered event correctly. Observation inflation is one such error of source monitoring. It refers to remembering the actions of another agent as self-performed.

Endomyocardial biopsy in patients with myocarditis-still justified in the CMR era? A single-centre experience.

Background: In the past decades, cardiovascular magnetic resonance (CMR) was established as a non-invasive tool supporting the diagnosis of myocarditis and there is often reluctance in performing EMB due to potentially severe complications. We sought to identify patient subgroups that could still benefit from EMB in the CMR era.

Methods: Data of patients presenting with myocarditis between 01/2016 and 06/2023 were analysed according to patient risks.