Test of theory of foraging mode: Goldcrests, , forage by high-yield, energy-expensive hovering flight when food is abundant but use low-yield, low-cost methods when food is scarce.

Here, I describe foraging behavior of goldcrests, , based on eight years of field observation in a coniferous forest dominated by Norway spruce in southwestern Sweden. The aim was to test predictions from theory on the choice of optimal foraging modes in relation to food availability.Mortality from early November to early March amounts to 70-86% among goldcrests in the resident population, suggesting they are food-limited in winter.

To minimize foraging time, use high-efficiency, energy-expensive search and capture methods when food is abundant but low-efficiency, low-cost methods during food shortages.

Based on a mathematical model, I show that the amount of food in the habitat determines which among alternative methods for search of prey, respectively, for pursuit-and-capture give the shortest daily foraging time. The higher the locomotor activity, the higher the rate of energy expenditure and the larger the habitat space a predator can search for prey per time unit. Therefore, I assume that the more efficient a foraging method is, the higher its rate of energy expenditure.

Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model.

P-cadherin-LP-DART is a bispecific antibody targeting P-cadherin expressed on the tumor cells and CD3 on the T-cells. Previously we demonstrated the development and efficacy of P-cadherin-LP-DART in and models. Here, we evaluated the three pillars: exposure, targeting specificity and pharmacodynamic modulation for P-cadherin-LP-DART using fluorescence molecular tomography (FMT).

Biodistribution and Targeting of Anti-5T4 Antibody-Drug Conjugate Using Fluorescence Molecular Tomography.

Understanding a drug's whole-body biodistribution and tumor targeting can provide important information regarding efficacy, safety, and dosing parameters. Current methods to evaluate biodistribution include in vivo imaging technologies like positron electron tomography and single-photon emission computed tomography or ex vivo quantitation of drug concentrations in tissues using autoradiography and standard biochemical assays. These methods use radioactive compounds or are cumbersome and do not give whole-body information.