Publications by authors named "R E Nicholson"
Article Synopsis
- Sphingolipids like ceramides play a significant role in high-fat diets and can influence fatty acid oxidation and intestinal stem cell (ISC) proliferation, potentially leading to cancer risk.
- The study manipulated the ceramide synthesis pathway in midgut intestinal cells to observe how changes in enzyme activities impacted cell behavior, revealing significant alterations in ISC proliferation and cell characteristics.
- Findings suggest that increased levels of saturated sphingolipids trigger inflammation in the gut, which in turn stimulates ISC proliferation through specific pro-inflammatory signals.
Article Synopsis
- A significant number of individuals with migraines, 45.1%, hesitate to seek medical care, which could limit effective treatment and management of their condition.
- The OVERCOME (US) survey utilized machine learning and regression models to identify key factors influencing this hesitation, such as stigma and personal management efforts.
- Common reasons for not seeking help include a desire to self-manage migraines and beliefs that their headaches might not warrant professional attention.
Milk foams are fragile objects, readily prepared for frothy cappuccinos and lattes using bovine milk. However, evolving consumer preferences driven by health, climate change, veganism, and sustainability have created a substantial demand for creating frothy beverages using plant-based milk alternatives or plant milks. In this contribution, we characterize maximum foam volume and half-lifetime as metrics for foamability and foam stability and drainage kinetics of two animal milks (cow and goat) and compared them to those of the six most popular, commercially available plant milks: almond, oat, soy, pea, coconut, and rice.
View Article and Find Full Text PDFBackground And Objectives: Preoperative red blood cell (RBC) transfusions increase post-operative venous thromboembolic (VTE) events. Erythropoietin-stimulating agents (ESAs) increase VTE risk in cancer patients; we aimed to assess ESA versus RBC-associated VTE risks in a broad population of surgical patients.
Materials And Methods: We queried TriNetX Diamond Network from 2006 to 2023, comparing patients with anaemia within 3 months preoperatively who received preoperative ESAs with or without intravenous (IV) iron to patients who received preoperative RBCs.
Like 'influencers' who achieve fame and power through social media, ceramides are low abundance members of communication platforms that have a mighty impact on their surroundings. Ceramide microdomains form within sphingolipid-laden lipid rafts that confer detergent resistance to cell membranes and serve as important signaling hubs. In cells exposed to excessive amounts of saturated fatty acids (e.
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