Myopathy in Statin-Treated Children and Adolescents: A Practical Approach.

Purpose Of Review: This paper reviews the existing literature on statin-related myopathy in children and adolescents, to inform development of a practical management approach.

Recent Findings: Reports of statin treatment in the pediatric population revealed no evidence of muscle pathology, with asymptomatic elevation of creatine kinase(CK) levels and symptoms of muscle pain without CK elevation seen equally in subjects and controls in RCTs. By contrast, rare cases of rhabdomyolysis have now been documented in statin-treated children; this serious problem had never been previously reported.

Combined Dyslipidemia in Children and Adolescents: a Proposed New Management Approach.

Purpose Of Review: Combined dyslipidemia (CD), the predominant abnormal lipid pattern in children and adolescents, is characterized by moderate/severe triglyceride elevation with reduced high-density lipoprotein cholesterol. CD is prevalent, present in 30-50% of obese adolescents. Epidemiologic and lipid sub-population findings demonstrate CD to be highly atherogenic.

Effectiveness and Safety of Statin Therapy in Children: A Real-World Clinical Practice Experience.

Background: Statin use for hypercholesterolemia in children is predominantly reported from short-term clinical trials. In this study, we assess the efficacy and safety of statin treatment in clinical pediatric practice.

Methods: Records of all patients who began statin treatment at age <18 years and remained on statins for >6 months from 5 pediatric lipid clinics were reviewed.