Publications by authors named "R E Kaminski"
In this work, we disclose a series of seven quadrupolar centrosymmetric 1,4-dihydropyrrolo[3,2-]pyrroles (DHPPs) linked to the two peripheral, strongly electron-accepting heterocycles such as benzoxadiazole, benzothiadiazole and benzoselenadiazole. This represents the first study probing the influence of electron-deficient heterocycles, rather that small electron-withdrawing substituents, on photophysics of DHPPs. These new acceptor-donor-acceptor hybrid dyes exhibit an appreciable combination of photophysical properties including absorption maxima in the range of 470-620 nm, and emission in the range of 500-720 nm with fluorescence quantum yields reaching 0.
View Article and Find Full Text PDFObjective: Excitotoxicity is a common hallmark of epilepsy and other neurological diseases associated with elevated extracellular glutamate levels. Thus, here, we studied the protective effects of (R)-AS-1, a positive allosteric modulator (PAM) of glutamate uptake in epilepsy models.
Methods: (R)-AS-1 was evaluated in a range of acute and chronic seizure models, while its adverse effect profile was assessed in a panel of standard tests in rodents.
Response/recommendation: The use of surgical drains in routine primary total knee and total hip arthroplasty is not recommended.
Level Of Evidence: High.
Expert Voting: Agree 83.
The rare observation of transient Rh···Rh excimer formation in a single crystal is reported. The estimated excited-state lifetime at 100 K is 2 ns, which makes it the shortest-lived small-molecule species caught experimentally using the laser-pump/X-ray-probe time-resolved Laue method. Upon excitation with 390 nm laser light, the intermolecular Rh···Rh distance decreases from 3.
View Article and Find Full Text PDFArticle Synopsis
- Shigellosis is a major cause of diarrheal deaths in children under five, and there's currently no effective vaccine for Shigella infection, particularly in endemic areas.
- Researchers in Bangladesh studied the antibody responses in both young children and older individuals with confirmed shigellosis to understand the differences in immune response.
- Findings revealed that while higher antibody levels correlated with less severe disease, young children developed weaker and less effective immune responses compared to older individuals, which may hinder their ability to fight off Shigella effectively.