Publications by authors named "R E Kalb"
Glioblastomas (aka Glioblastoma multiformes (GBMs)) are the most deadly of the adult brain tumors. Even with aggressive treatment, the prognosis is extremely poor. The large GTPase Guanylate-Binding Protein-1 (GBP-1) contributes to the poor prognosis of GBM by promoting migration and invasion.
View Article and Find Full Text PDFArticle Synopsis
- The study compares the effectiveness of home-based vs. office-based phototherapy for psoriasis, highlighting that while office therapy is cost-effective, it’s often hard to access compared to the more patient-preferred home therapy, which lacks sufficient clinical data, especially for those with darker skin.
- Conducted across 42 dermatology practices in the US, the trial involved 783 participants aged 12 and older with psoriasis, who were randomly assigned to either home or office phototherapy for 12 weeks, followed by another 12 weeks of observation.
- Results showed that home phototherapy led to better skin clearance and quality of life improvements, with 32.8% of participants achieving clear skin compared to
Protein misfolding and aggregation are cardinal features of neurodegenerative disease (NDD) and they contribute to pathophysiology by both loss-of-function (LOF) and gain-of-function (GOF) mechanisms. This is well exemplified by TDP-43 which aggregates and mislocalizes in several NDDs. The depletion of nuclear TDP-43 leads to reduction in its normal function in RNA metabolism and the cytoplasmic accumulation of TDP-43 leads to aberrant protein homeostasis.
View Article and Find Full Text PDFArticle Synopsis
- Biosimilars, like infliximab and rituximab, can enhance access to effective medications, with new versions of adalimumab expected in 2023.
- This review examines the basics of biosimilars and their use in dermatology across the US, Asia, and Europe, based on extensive literature from 2015 to early 2023.
- Although biosimilars have achieved significant savings and market share growth in Europe, the same success has not yet been mirrored in the US, highlighting the need for better prescribing incentives and physician education.
Ionic liquids (ILs) are an emerging materials' class with applications in areas such as energy storage, catalysis, and biomass dissolution and processing. Their physicochemical properties including surface tension, viscosity, density and their interplay between cation and anion chemistry are decisive in these applications. For many commercially available ILs, a full set of physicochemical data is not available.
View Article and Find Full Text PDF