[Morphological characteristics of cardiomyocyte death in the experimental myocardial infarction in rats with various emotional reaction].

The peculiarities of morphological signs of cardiomyocyte death in the lesion focus in experimental myocardial infarction were studied. Infarction was induced by ligation of descending branch of the left heart coronary artery in outbred rats with 180-200 g body mass, which were previously subdivided into highly emotional (HE) and low emotional (LE) groups according to "open field" test. Microscopic study has shown that in the infarction focus of animals of both HE and LE groups cardiomyocyte death types were found that differed primarily by the state of myofibrils.

[Morphological peculiarities of rat liver reaction to chronic xenobiotic exposure].

The data of the morphological studies of liver of animals subjected to chronic (3 months long) intoxication with different chemical substances (ammonium nitrogen, nitrite nitrogen, fluorine, chromium, arsenic) are presented. The xenobiotics tested induced stereotyped responses in liver which differed in their intensity and the extent of hemomicrocirculatory and inflammatory-destructive alterations. Most pronounced reactive changes were found in animals exposed to arsenic compounds, while sodium nitrate caused practically no destructive changes in hepatocytes.

[Pathogenetic validation of the development of early and complicated menopause].

Results have been studied of case histories, clinical-and-functional, and pathomorphological investigations on ovaries in 82 women presenting with early and complicated climacterium, who had undergone ovarian surgery for tumour formations. In those women who ranged from 18 to 34 years old and presented with a most aggravated hereditary antecedent history morphological changes were characterized by development of sclerotic, atrophic, and dysregenerative processes in the parenchyma of the ovary. In women aged 35-42 years with aggravated gynecological past history morphological changes in the ovaries were characterized by predominance of inflammatory processes involving mononuclear cells of lymphoid and histiocytic origin and by development of cystic dilation of folliculi and diminution of the volume of granulosa and luteinic cells due to development of the atrophic process.

Morphological changes in myocardium in rats with different resistance to hypoxia after ligation of the coronary artery.

We studied morphological changes in the myocardium during experimental myocardial infarction in rats with different resistance to hypoxia. Microscopic examination showed that morphological changes in the ischemic zone and adjacent tissues are different in rats with high and low resistance to acute ischemia. In highly resistant rats, necrotic changes in cardiomyocytes included focal contracture and loosening.