Publications by authors named "R E Hinkley"

Purpose: To assess students' perceptions of the extent of diversity in their classes, the role of diversity in their first-year curriculum, and their predictions of the amount of diversity in their future patient populations.

Method: In 1998, students at four southeastern U.S.

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The demographic and academic profiles of first-year classes entering the three allopathic medical schools in Florida (UM, UF, and USF) between 1990 and 1996 have been summarized. In general, the high academic standards for admission (high GPAs and MCAT scores) have been maintained, and in some cases, increased. The percentages of women admitted to the first-year classes at UM and UF have increased in recent years, and the number of women enrolled in MD programs in Florida has increased by 26% since 1990.

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When sea urchin eggs are pretreated with fluorescent chelate probe chlorotetracycline (CTC) and then fertilized with unlabeled sperm, a small, brightly fluorescent particle resembling the mitochondrion of free-swimming sperm both in size and fluorescent staining characteristics appears in the egg cytoplasm. This particle first appears near the base of the insemination cone and, like the paternal mitochondrion identified in previous ultrastructural studies, remains closely associated with the male pronucleus during its microtubule-dependent migration toward the egg center. These similarities strongly suggest that the fluorescent particle observed in the cytoplasm of living, CTC-pretreated sea urchin eggs is, in fact, the mitochondrion of the fertilizing sperm.

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Chlortetracycline (CTC) has been used to study sequential changes in the distribution of calcium-sequestering membranes during the first cell cycle of fertilized sea urchin eggs CTC staining patterns first appear as a diffuse ring around the centered zygote nucleus at the time of syngamy. As development proceeds, the ring becomes brighter and then elongates concurrently with the formation of the streak apparatus. Fluorescence subsequently accumulates in the centrospheres of the developing mitotic apparatus and is present in mitotic asters throughout mitosis.

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