Publications by authors named "R E Halliwell"
Repeated and uncontrolled seizures in epilepsy result in brain cell loss and neural inflammation. Current anticonvulsants primarily target ion channels and receptors implicated in seizure activity. Identification of neurotherapeutics that can inhibit epileptiform activity and reduce inflammation in the brain may offer significant benefits in the long-term management of epilepsy.
View Article and Find Full Text PDFObjective: Mental health education can reduce the stigma held by medical and nursing students; however, findings in this regard are limited in pharmacy academia. This study investigated the impact of a neuropsychiatric therapeutics course followed by a case-based course on the mental health stigma held by pharmacy students.
Methods: A survey was conducted of second-year pharmacy students (n = 202) on the first and last day of a neuropsychiatric therapeutics course and 4 months later, at the end of a case-based course.
Modeling the complex and prolonged development of the mammalian central nervous system remains a profound challenge. Most studies of human stem cell derived neurons are conducted over days to weeks and may or may not include glia. Here we have utilized a single human pluripotent stem cell line, TERA2.
View Article and Find Full Text PDFArticle Synopsis
- - Peri-operative cardiovascular events affect up to 3% of patients having non-cardiac surgery, making accurate risk assessment essential for deciding whether to proceed with surgery and for planning the care approach.
- - Assessing cardiovascular risk pre-surgery involves evaluating clinical history and estimating functional capacity, without the need for specialized cardiac tests in most cases.
- - Current guidelines advise against pre-operative revascularization to enhance post-operative outcomes, emphasizing that decisions should be based on the specifics of the surgery rather than routine cardiac investigations.
Human stem cell-derived neurons are increasingly considered powerful models in drug discovery and disease modeling, despite limited characterization of their molecular properties. Here, we have conducted a detailed study of the properties of a commercial human induced Pluripotent Stem Cell (iPSC)-derived neuron line, iCell [GABA] neurons, maintained for up to 3 months in vitro. We confirmed that iCell neurons display neurite outgrowth within 24 h of plating and label for the pan-neuronal marker, βIII tubulin within the first week.
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