Publications by authors named "R E Gonzalez-Castaneda"

Attention Deficit Hyperactivity Disorder is a neurodevelopmental disorder with three presentations: inattentive, hyperactive/impulsive and combined. These may represent an independent disease entity. Therefore, the therapeutic approach must be focused on their neurobiological, psychological and social characteristics.

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The development of type 2 diabetes mellitus (T2DM) vascular complications (VCs) is associated with oxidative stress and chronic inflammation and can result in endothelial dysfunctions. Circulating microRNAs play an important role in epigenetic regulation of the etiology of T2DM. We studied 30 healthy volunteers, 26 T2DM patients with no complications, and 26 T2DM patients with VCs, to look for new biomarkers indicating a risk of developing VCs in T2DM patients.

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Article Synopsis
  • Oligodendrocyte loss and myelin damage are key features of demyelinating diseases, and this study examines the effects of phenytoin on myelin recovery in demyelinated mice.
  • Male mice were treated with a demyelinating agent and divided into a phenytoin-treated group and a control group, with the treated group receiving phenytoin for 4 weeks.
  • Results showed that phenytoin significantly increased oligodendrocyte precursor cells and myelin basic protein levels, leading to improved motor coordination and muscle strength in the treated mice compared to the control group.
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Background: Autism Spectrum Disorder (ASD) is considered a neurodevelopmental condition that is characterized by alterations in social interaction and communication, as well as patterns of restrictive and repetitive behaviors (RRBs). RRBs are defined as broad behaviors that comprise stereotypies, insistence on sameness, and attachment to objects or routines. RRBs can be divided into lower-level behaviors (motor, sensory, and object-manipulation behaviors) and higher-level behaviors (restrictive interests, insistence on sameness, and repetitive language).

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