Publications by authors named "R E Gandley"
Background: Gestational diabetes mellitus (GDM) is associated with increased long-term risk of cardiovascular disease but the cardiovascular structural and functional changes that contribute to risk are not well understood.
Objectives: The purpose of this study was to determine whether GDM is associated with adverse cardiac remodeling and endothelial dysfunction a decade after delivery, independent of type 2 diabetes.
Methods: Women with deliveries between 2008 and 2009 were initially selected from a prospective clinical cohort.
Background: Hypertensive disorders of pregnancy (HDP) are associated with subsequent adverse cardiac remodeling and cardiovascular disease. The role of myocardial microvascular disease among individuals with HDP and left ventricular (LV) remodeling as a potential link to cardiovascular disease is unknown. We aimed to determine whether individuals with HDP history have coronary microvascular dysfunction measured by coronary flow reserve 8 to 10 years after delivery and whether microvascular dysfunction correlates with LV remodeling.
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- The study compared sleep quality one year after childbirth between individuals with persistent postpartum hypertension (HTN) and those with normal blood pressure after experiencing a hypertensive disorder of pregnancy (HDP).
- Researchers analyzed data from two studies, finding that 45% of participants had persistent postpartum HTN, which was associated with factors like being older, having a higher BMI, and being of Black race.
- On average, participants reported poor sleep quality, with those having persistent postpartum HTN scoring worse on the Pittsburgh Sleep Quality Index, indicating a significant correlation between hypertension and sleep issues.
Article Synopsis
- Preeclampsia (PE) is a common pregnancy issue that is more likely to occur in women with obesity, although only a small percentage of these women actually develop PE.
- Researchers studied women with obesity during pregnancy to find specific lipid markers that could indicate the presence of PE, using blood samples collected throughout the trimesters.
- The study found that targeted lipid analysis revealed higher levels of certain lipids in the third trimester for women with PE, while earlier trimesters showed no predictive lipid differences; race and pregnancy stage also influenced lipid variations.
Preeclampsia is a multisystem disorder that affects maternal endothelium. The glycocalyx lines and protects the endothelial surface. In severe systemic diseases, like sepsis, it is shed and glycocalyx degradation products can be detected in increased concentrations in plasma.
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